Optimization of PEG 400 and PEG 6000 in Simplicia Ointment of Laportea decumana (Roxb.) Wedd

Introduction: The Papuan people have utilized the native herb Laportea decumana (Roxb.) Wedd for centuries to treat aches and pains L. is used by attaching leaves to the body area with illness. Methods: This study aimed test optimal composition of PEG 400 and 6000 in L.decumana  simplicia ointment formula produce a good physical quality ointment. employed three designs made up mixture (A): (B) ratios 65%:35%, 50%:50%, 35%:65%, respectively, using simplex lattice design approach. Physical qualities created ointment, such as organoleptic, homogeneous, miscibility, stickiness, pH, acceptability tests, were performed on it. Next, results properties response calculated obtain optimum formula. The One-Sample T-test 95% confidence level was compare experimental findings formulation expected optimization Result: indicated that 400: 60%: 40% which having spread 3.63 cm; pH 9.2 test; stickiness 7.5 seconds. showed there non-significant difference between predicted p>0.05. Conclusion: itchy can be formulated specific had quality.